G. S. Research Group
Dr. Gangarajula Sudhakar
Sr. Principal Scientist
Dept. of Organic Synthesis & Process Chemistry
CSIR- Indian Institute of Chemical Technology
Hyderabad-500007
34. Chennam Ramu, Manthani Shiva Kumar, Avula Shivakrishna, Thenkrishnan Kumaraguru, Subhash Ghosh, Chada Raji Reddy, and Gangarajula Sudhakar* "Development of a Concise Synthetic Approach to Gliflozin Aglycones from Regioselective-Deprotonation of 1,4-Dihalobenzenes" Journal of Organic Chemistry 2025, (DOI: doi.org/10.1021/acs.joc.4c02914).
33. Amit Kumar, Gaddam Mahesh, Jagadeesh Babu Nanubolu, Gangarajula Sudhakar* "Electrocyclization of Arylvinyl Oxetane/1,3-Diol to Substituted Indenyl Acetaldehyde via Indene–Ethanol, Oxepine, and a 1,6-Hydride Shift" Journal of Organic Chemistry 2025, 90, 2800-2805 (https://doi.org/10.1021/acs.joc.4c03126)
32. Himalaya Singh, Nagam Satish, Tella Ramesh Babu, Abhinav Singh, Babita Yadav b,e, Sandeep Kumar Singh, Mohammad Wahajuddin, Mohammad Imran Siddiqui, Kumaravelu Jagavelu,* Gangarajula Sudhakar* "Functionalized azirine based scaffolds as endothelin inhibitors for the selective anti-angiogenic activity" European Journal of Medicinal Chemistry 2024, 274, 116510 (doi.org/10.1016/j.ejmech.2024.116510).
31. Chennam Ramu, T. Kumaraguru, M. Sridhar Reddy, Haridas B. Rhode, Subhash Ghosh, Ch. Raji Reddy, and Gangarajula Sudhakar* "Synthesis of Ledipasvir through a Late-Stage Cyclopropanation and Fluorination Process" Synthesis 2024, 56, 603 (DOI: 10.1055/s-0042-1751437; Art ID: SS-2022-10-0494-ST).
30. Kishore Kumar Palli, Palash Ghosh, Shiva Krishna Avula, B. Sridhara Shanmukha Rao, Amol D. Patil, Subhash Ghosh, Gangarajula Sudhakar, Chada Raji Reddy, Prathama S. Mainkar, Srivari Chandrasekhar* "Total synthesis of remdesivir" Tetrahedron Letters 2022, 88, 153590 (doi.org/10.1016/j.tetlet.2021.153590).
29. Mithun Chakraborty,* Gaddam Mahesh, Omkar R. Nakel, Gautamee Chavda, Susarla Anusha, and Gangarajula Sudhakar "A Facile Approach to Access Multi-Substituted Indenes via Nazarov Cyclisation of Aryl, Vinyl, and Alkyl/Aryl Carbinols" ChemistrySelect 2021, 6, e202103141 (doi.org/10.1002/slct.202103141).
28. Nagam Satish, Siruvuri Krishnam Raju, Jagadeesh Babu Nanuboluc and Gangarajula Sudhakar* "The synthesis of indeno[de]isochromene derivatives from arylvinyl epoxides and carbonyl compounds via tandem Nazarov and oxa-Pictet–Spengler cyclizations" New Journal of Chemistry 2021, 16248-16253 (doi.10.1039/d1nj03654h).
27. B. Sridhara Shanmukha Rao, Chennam Ramu, Gangarajula Sudhakar* "Total Synthesis of Alstofonidine via its Putative Biosynthetic Congener" Tetrahedron 2021, 82, 131930 (doi.org/10.1016/j.tet.2021.131930).
26. Nagam Satish and Gangarajula Sudhakar* "Scandium Triflate Catalyzed Nazarov Cyclization of Arylvinyl Epoxides Derived from Alkoxides and Chloro(aryl)carbenes: A Facile Access to Resveratrol-Derived Natural Products" Synlett 2020, 605-610.
25. Avula Shiva Krishna, Shalini Basetty, Rajesh Nasam, Samuel L. Ralte, Chada Raji Reddy, Gangarajula Sudhakar, Srihari Pabbaraja, Srivari Chandrasekhar, Prathama S. Mainkar, Thenkrishnan Kumaraguru,* and Subhash Ghosh* "Chemoenzymatic Process for the Preparation of (S)‑7-((tertButyldiphenylsilyl)oxy)hept-1-yn-4-ol in a Continuous Packed-Bed Reactor, a Key Intermediate for Eribulin Synthesis" Organic Process Research & Development 2020, 24, 2657.
24. Gaddam Mahesh, Jakka Raghavaiah, and Gangarajula Sudhakar* "A Unified Approach to the Salicylaldehyde Containing Polyketide Natural Products: Total Synthesis of ent-Pyriculol, ent-Epipyriculol, ent-Dihydropyriculol, ent-Epidihydropyriculol, Sordariol, Sordarial, 12-Methoxy Sordariol, and Agropyrenol" Tetrahedron 2020, 76, 131368.
23. Sridhara Shanmukha Rao B., Amit Kumar, and Gangarajula Sudhakar* "Total Synthesis of Alstofolinine A" Asian J. Org. Chem. 2020, 9, 1172-1173.
22. Mithun Chakraborty, Gaddam Mahesh, Omkar R. Nakel, Gautamee Chavda, Susarla Anusha, and Gangarajula Sudhakar* "Synthesis of multi-substituted indene derivatives from aryl, vinyl, and alkyl/aryl carbinols" Beilstein Archives. 2019 doi.org/10.3762/bxiv.2019.39.v1.
21. S. K. Mahesh, Jagadeesh Babu Nanubolu, and Gangarajula Sudhakar* "Tandem Addition/Electrocyclization/Benzylation of Alkyl Aryl-1,3- dienes and Aromatic Aldehydes: Access To Highly Substituted Indenes" Journal of Organic Chemistry 2019, 84, 7815-7828 (DOI: 10.1021/acs.joc.9b00679).
20. Vilas D. Kadam, Sridhara Shanmukha Rao, S. K. Mahesh, Mithun Chakraborty, S. Phani Babu Vemulapalli, Satya Narayana Dayaka, and Gangarajula Sudhakar* "Stereoselective Access to the Core Structure of Macroline-Type Indole Alkaloids: Total Synthesis of Macroline and Alstomicine" Organic Letters 2018, 20, 4782-4786.
19. Gangarajula Sudhakar,* S. K. Mahesh, S. Phani Babu Vemulapalli, and Jagadeesh Babu Nanubolu "Nazarov Cyclization and Tandem [4 + 2]-Cycloaddition Reactions of Donor−Acceptor Cyclopropanes" Organic Letters 2017, 19, 4500-4503.
18. Gangarajula Sudhakar,* Jakka Raghavaiah, Gaddam Mahesh, and Kiran Kumar Singarapu "Nazarov cyclization of divinyl ketones bearing an ester group at the β-position: a remarkable effect of α-substitution and alkene geometry on regioselectivity" Organic and Biomolecular Chemistry 2016, 14, 2866-2872.
17. Vilas D. Kadam, and Gangarajula Sudhakar* "Total synthesis of motualevic acids A-F, (E) and (Z)-antazirines" Tetrahedron 2015, 71, 1058-1067.
16. Kovela Satish, Galla Srihari, Gangarajula Sudhakar, Kura Narsimha, Tadikamalla Prabhakar Rao, Madugula Marthanda Murthy* "Two new diterpenpids from the roots of Pygmacopremna herbacea" Phytochemistry Letters 2015, 12, 129-132.
15. Gangarajula Sudhakar,* Karla Janardhan Reddy, Jagadesh Babu Nanubolu "Nazarov cyclization of dienylaziridines: synthesis of cyclopentadienyl/ hydrinedienyl/ indenyl glycines"Organic and Biomolecular Chemistry 2015, 13, 8875-8885.
14. Gangarajula Sudhakar,* and Kovela Satish "Nazarov Cyclization of Divinyl, Arylvinyl Epoxides: Application in the Synthesis of Resveratrol-Based Natural Products" Chemistry-A European Journal 2015, 21, 6475-6480.
13. Gangarajula Sudhakar,* Shruthi Bayya, Vilas D. Kadam, and Jagadeesh Babu Nanubolu "Total Synthesis of Gonytolides C and G, Lachnone C, and Formal Synthesis of Blennolide C and Diversonol" Organic and Biomolecular Chemistry 2014, 12, 5601-5610.
12. Gangarajula Sudhakar,* Shruthi Bayya, Karla Janardhan Reddy, Balasubramanian Sridhar, Komal Sharma, and Surendar Reddy Bathula* "Synthesis and cytotoxicity of the proposed structure of piperazirum, its stereoisomers and analogues" European Journal of Organic Chemistry 2014, 1253-1265.
11. Gangarajula Sudhakar,* and Jakka Raghavaiah "Total synthesis of varitriol, varioxirane, and enantiomer of the proposed biosynthetic precursor" Journal of Organic Chemistry 2013, 78, 8840-8846.
10. Gangarajula Sudhakar,* Karla Janardhan Reddy, Jagadeesh Babu Nanubolu "Total synthesis of palmyrolide A and it's 5,7-epi isomers" Tetrahedron 2013, 69, 2419-2429.
9. Arun K. Ghosh,* Satyendra Pandey, Sudhakar Gangarajula, Sarang Kulkarni, Xiaoming Xu, Kalapala Venkateswara Rao, Xiangping Huang, Jordan Tang "Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors" Bioorganic & Medicinal Chemistry Letters 2012, 22, 5460-5465.
8. Gangarajula Sudhakar,* Kovela Satish, Jakka Raghavaiah "Total Synthesis and Absolute Configuration of Curvularides A-E" Journal of Organic Chemistry 2012, 77, 10010-10020.
7. Gangarajula Sudhakar,* Vilas D. Kadam, Shruthi Bayya, Gavinolla Pranitha and Bharatam Jagadeesh "Total synthesis and stereochemical revision of acortatarins A and B" Organic Letters 2011, 13, 5452-5455.
6. Gangarajula Sudhakar,* Vilas D. Kadam and Vaddu V. N. Reddy "Total synthesis of motualevic acids A-E" Tetrahedron Letters 2010, 51, 1124-1125.
5. Tushar K. Chakraborty* and Gangarajula Sudhakar "Total Synthesis of (+)-Conagenin" Tetrahedron Letters 2006, 47, 5847-5849.
4. Tushar K. Chakraborty* and Gangarajula Sudhakar "Stereoselective synthesis of the various isomers of 3,4-dideoxy furanoid sugar amino acids with methyl substitution at the C6 position" Tetrahedron Letters 2005, 46, 4287-4290.
3. A.Matur, M. Jaggi, R. Sharma, N. Gupta, V.R. Reddy, G. Sudhakar, S. U. Kumar, S. K. Kumar, A. C. Kunwar*and T. K. Chakraborty* "Furanoid sugar amino acids as dipeptide mimics in design of analogs of vasoactive intestinal peptide receptor binding inhibitor" J. Peptide Res. 2005, 66, 75-84.
2. Tushar K. Chakraborty* and Gangarajula Sudhakar "Synthesis of C6 substituted 3,4-dideoxy furanoid sugar amino acids" Tetrahedron Asymmetry 2005, 16, 7-9.
1. Tushar K. Chakraborty*, V. Ramkrishna Reddy, G. Sudhakar, S. Uday Kumar, T. Jagadeshwar Reddy, S. Kiran Kumar, Ajit C. Kunwar,* Archana Mathur, Rajan Sharma, Neena Gupta and Sudhanand Prasad "Conformational studies of 3,4-dideoxy furanoid sugar amino acid containing analogs of the receptor binding inhibitor of vasoactive intestinal peptide"Tetrahedron 2004, 60, 8329-8339.